⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935229 | 0.70 | — | — | |
| SCHEMBL392829 | 0.70 | — | — | |
| SCHEMBL723777 | 0.70 | — | — | |
| SCHEMBL14859078 | 0.70 | — | — | |
| SCHEMBL935675 | 0.70 | — | — | |
| SCHEMBL940899 | 0.70 | — | — | |
| SCHEMBL28258686 | 0.70 | — | — | |
| SCHEMBL68370 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL7393663 | 0.68 | — | — | |
| Iodide SCHEMBL28915985 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735431-A2 | MK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | GILEAD SCIENCES, INC. (US) | 2026-05-06 | — | — | EP | disclosed |
| US-20250051309-A1 | MK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | GILEAD SCIENCES, INC. | 2025-02-13 | — | — | US | disclosed |
| WO-2025006568-A2 | MK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | GILEAD SCIENCES, INC. (US) | 2025-01-02 | — | — | WO | disclosed |
| WO-2022149593-A1 | PLANT GROWTH REGULATOR AND METHOD FOR PROMOTING PLANT GROWTH | 株式会社クレハ | 2022-07-14 | — | — | WO | disclosed |
| CN-108948003-A | Pyrazine as mTOR inhibitors simultaneously [2,3-c] quinoline -2(1H) -one class compound preparation and purposes | 南开大学 | 2018-12-07 | — | — | CN | disclosed |
| US-9233937-B2 | Method of stimulating insulin secretion and/or modulating INS-1 kinase with substituted pyrazinones and/or substituted tetrahydroquinoxalinones | MERCK PATENT GMBH (FR) | 2016-01-12 | — | — | US | disclosed |
| US-9102632-B2 | Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes | MERCK PATENT GMBH (DE) | 2015-08-11 | — | — | US | disclosed |
| EP-2250156-B1 | PYRAZINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2015-05-06 | — | — | EP | disclosed |
| US-20140329837-A1 | ARYLPYRAZINONES SUCH AS BUT NOT LIMITED TO 3-(4-CHLOROPHENYL-1-ETHYLPYRAZIN-2-(1H0)-ONE | MERCK PATENT GMBH (FR) | 2014-11-06 | — | — | US | disclosed |
| US-8815859-B2 | Substituted pyrazin-2-ones and substituted 5,6,7,8-tetrahydroquinoxalin-2-ones and methods of use thereof | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-6476016-B2 | INHIBITING LOSS OF BLOOD PLATELETS, INHIBITING FORMATION OF BLOOD PLATELET AGGREGATES, INHIBITING FORMATION OF FIBRIN, INHIBITING THROMBUS FORMATION, AND INHIBITING EMBOLUS FORMATION | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | disclosed |
| WO-2002064140-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
| US-20020052357-A1 | Cyclic oxyguanidine pyrazinones as protease inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-05-02 | — | — | US | disclosed |
| EP-0927171-B1 | PYRAZINONES AND TRIAZINONES AND THEIR DERIVATIVES THEREOF | DU PONT PHARM CO (US) | 2002-02-20 | — | — | EP | disclosed |
| WO-2002006248-A2 | CYCLIC OXYGUANIDINE PYRAZINONES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-01-24 | — | — | WO | disclosed |
| US-6218391-B1 | CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS USED IN THERAPY OF PSYCHIATRIC DISORDERS AND NEUROLOGICAL DISEASES SUCH AS MAJOR DEPRESSION, ANXIETY-RELATED DISORDER, POST-TRAUMATIC STRESS DISORDER, SUPRANUCLEAR PALSY | DUPONT PHARMACEUTICALS COMPANY | 2001-04-17 | — | — | US | disclosed |
| US-6159980-A | Pyrazinones and triazinones and their derivatives thereof | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0927171-A1 | PYRAZINONES AND TRIAZINONES AND THEIR DERIVATIVES THEREOF | Du Pont Pharmaceuticals Company (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998011075-A1 | PYRAZINONES AND TRIAZINONES AND THEIR DERIVATIVES THEREOF | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-03-19 | — | — | WO | disclosed |
| EP-0135714-B1 | SUSTAINED RELEASE COMPOSITIONS FOR BIOLOGICALLY ACTIVE MATERIALS | MELAMINE CHEMICALS, INC. (US) | 1991-11-06 | — | — | EP | disclosed |