Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 9/20 | 0.52 |
| ▸ | ERN1 | O75460 | 4/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936143 | 0.86 | PRKD1 (0.54) | PRKD1ERN1BCHEACHEMAPT | |
| SCHEMBL17279928 | 0.86 | MAPT (0.54) | PRKD1ERN1BCHEACHEMAPT | |
| SCHEMBL961205 | 0.85 | PRKD1 (0.53) | PRKD1BCHEACHEMAPTSMN1; SMN2 | |
| SCHEMBL6923037 | 0.85 | PRKD1 (0.70) | PRKD1ERN1BCHEACHE | |
| SCHEMBL17279929 | 0.85 | PRKD1 (0.54) | PRKD1BCHEACHEMAPTSMN1; SMN2 | |
| SCHEMBL936198 | 0.82 | PRKD1 (0.53) | PRKD1BCHEACHEMAPTSMN1; SMN2 | |
| SCHEMBL4887726 | 0.82 | ERN1 (0.68) | ERN1ALDH1A1GABRG2GABRB3GABRA5 | |
| SCHEMBL17279926 | 0.81 | MAPT (0.54) | PRKD1BCHEACHEMAPTSMN1; SMN2 | |
| SCHEMBL17279877 | 0.80 | GAA (0.59) | PRKD1BCHEACHEMAPTSMN1; SMN2 | |
| SCHEMBL14985491 | 0.80 | GAA (0.63) | BCHEACHEALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |