Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 10/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936143 | 0.89 | PRKD1 (0.54) | PRKD1BCHEACHEMAPTNPC1 | |
| SCHEMBL17279928 | 0.88 | MAPT (0.54) | PRKD1BCHEACHEMAPTRAB9A | |
| SCHEMBL17279929 | 0.87 | PRKD1 (0.54) | PRKD1BCHEACHEMAPTNPC1 | |
| SCHEMBL935612 | 0.85 | PRKD1 (0.52) | PRKD1BCHEACHEMAPTNPC1 | |
| SCHEMBL936255 | 0.84 | PRKD1 (0.73) | PRKD1BCHEACHE | |
| SCHEMBL936198 | 0.84 | PRKD1 (0.53) | PRKD1BCHEACHEMAPTNPC1 | |
| SCHEMBL17279926 | 0.83 | MAPT (0.54) | PRKD1BCHEACHEMAPTNPC1 | |
| SCHEMBL17279877 | 0.82 | GAA (0.59) | PRKD1BCHEACHEMAPTNPC1 | |
| SCHEMBL14985491 | 0.82 | GAA (0.63) | BCHEACHEMAPTNPC1RAB9A | |
| SCHEMBL8880508 | 0.81 | PLAU (0.64) | PLAUGABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |