Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8931451 | 0.98 | CHRNB4 (0.42) | CHRNB4CHRNA3EGFRPOLBCHRM2 | |
| SCHEMBL3215425 | 0.91 | CHRNB4 (0.47) | CHRNB4CHRNA3EGFRPOLBCHRM2 | |
| SCHEMBL8863847 | 0.84 | CHRNB4 (0.45) | CHRNB4CHRNA3EGFRPOLBCHRM2 | |
| Hydrochloric Acid SCHEMBL8864188 | 0.83 | CHRNB4 (0.44) | CHRNB4CHRNA3EGFRPOLBCHRM2 | |
| Hydrochloric Acid SCHEMBL10914610 | 0.80 | GAA (0.55) | HTR3ACYP2D6CHRNA7 | |
| SCHEMBL7330957 | 0.76 | LTA4H (0.50) | CHRM1CHRM3KCNH2 | |
| Hydrochloric Acid SCHEMBL7430573 | 0.75 | LTA4H (0.49) | CHRM1CHRM3KCNH2 | |
| SCHEMBL3214765 | 0.74 | CHRNB4 (0.50) | CHRNB4CHRNA3EGFRPOLBCHRM2 | |
| SCHEMBL13444728 | 0.74 | CHRNB4 (0.50) | CHRNB4CHRNA3EGFRPOLBCHRM2 | |
| SCHEMBL9541328 | 0.72 | USP30 (0.52) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626960-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-12-07 | — | — | EP | claimed |
| WO-1993013096-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-07-08 | — | — | WO | claimed |
| WO-1993013096-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-07-08 | — | — | WO | disclosed |