Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358255 | 1.00 | REN (0.50) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9354743 | 0.89 | REN (0.46) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9354750 | 0.89 | REN (0.46) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9355302 | 0.86 | REN (0.59) | REN | |
| SCHEMBL9355310 | 0.86 | REN (0.59) | REN | |
| SCHEMBL9354241 | 0.86 | REN (0.68) | REN | |
| SCHEMBL9354237 | 0.86 | REN (0.68) | REN | |
| SCHEMBL9358904 | 0.85 | REN (0.45) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9354262 | 0.85 | REN (0.45) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9354926 | 0.84 | REN (0.62) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |