SCHEMBL9358286

SCHEMBL9358286

Cc1cc(C)c2nc(C)c(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9359104 0.90 NPC1 (0.41) NPC1RAB9A
SCHEMBL7073167 0.85
Hydrochloric Acid SCHEMBL9163785 0.84
SCHEMBL9162892 0.81
SCHEMBL9359237 0.80 NPC1 (0.40) NPC1RAB9A
SCHEMBL9162732 0.80 EGFR (0.39)
SCHEMBL9359139 0.79 KDR (0.50) RAB9A
SCHEMBL9164497 0.79
SCHEMBL9358704 0.78 PKM (0.42)
SCHEMBL9159469 0.78 PKM (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0421456-B1 Quinoline derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1994-12-28 EP disclosed
US-5223513-A Anticholesterol agent TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-06-29 US disclosed