SCHEMBL9358463

SCHEMBL9358463

O=C(CCCNC(=S)Nc1ccc(Oc2ccccc2)cc1)NCCCOc1cccc(CN2CCCCC2)c1

nearest known ligand 0.72

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HRH2 P25021 1/20 0.58
HRH3 Q9Y5N1 1/20 0.58
FAAH O00519 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9358134 0.95 FAAH (0.62) HRH2HRH3FAAH
SCHEMBL9362343 0.94 FAAH (0.61) HRH2HRH3FAAH
SCHEMBL9358577 0.92 HRH2 (0.60) HRH2HRH3
SCHEMBL9362624 0.92 HRH2 (0.60) HRH2HRH3
SCHEMBL9476294 0.92 FAAH (0.60) HRH2HRH3FAAH
SCHEMBL9362356 0.91 HRH2 (0.59) HRH2HRH3
SCHEMBL9358452 0.89 HRH2 (0.56) HRH2HRH3
SCHEMBL9362605 0.89 HRH2 (0.59) HRH2HRH3
SCHEMBL9358523 0.87 HRH2 (0.61) HRH2HRH3
SCHEMBL9358153 0.87 HRH2 (0.62) HRH2HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0470006-B1 Thiourea derivatives and antimicrobial agent and antiulcer agent containing the same TERUMO CORP (JP) 1994-12-14 EP disclosed
US-5190961-A Bactericides TERUMO KABUSHIKI KAISHA (JP) 1993-03-02 US disclosed
EP-0470006-A1 Thiourea derivatives and antimicrobial agent and antiulcer agent containing the same TERUMO KABUSHIKI KAISHA (JP) 1992-02-05 EP disclosed