Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5868080 | 1.00 | KCNA5 (0.38) | KCNA5ABCB1IDO1PARP1CNR1 | |
| SCHEMBL6275053 | 1.00 | KCNA5 (0.38) | KCNA5ABCB1IDO1PARP1CNR1 | |
| SCHEMBL5868082 | 1.00 | KCNA5 (0.38) | KCNA5ABCB1IDO1PARP1CNR1 | |
| SCHEMBL2828711 | 0.81 | SELL (0.42) | ABCB1 | |
| SCHEMBL5868353 | 0.79 | IDO1 (0.40) | ABCB1IDO1 | |
| SCHEMBL5868357 | 0.79 | IDO1 (0.40) | ABCB1IDO1 | |
| SCHEMBL6274078 | 0.79 | IDO1 (0.40) | ABCB1IDO1 | |
| SCHEMBL8947007 | 0.78 | IDO1 (0.36) | ABCB1IDO1KCNE1KCNQ1 | |
| SCHEMBL8947011 | 0.78 | IDO1 (0.36) | ABCB1IDO1KCNE1KCNQ1 | |
| SCHEMBL482484 | 0.78 | KCNE1 (0.47) | KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430621-A2 | Process for the preparation of chiral 3,4-epoxy benzopyrans | Beecham Group p.l.c. (GB) | 1991-06-05 | — | — | EP | claimed |
| EP-0426379-B1 | Substituted cyclobutenedione compounds | BEECHAM GROUP PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| US-5147866-A | Hypotensive, bronchodilator agents | BEECHAM GROUP P.L.C. (GB) | 1992-09-15 | — | — | US | disclosed |
| EP-0430621-A2 | Process for the preparation of chiral 3,4-epoxy benzopyrans | Beecham Group p.l.c. (GB) | 1991-06-05 | — | — | EP | disclosed |
| EP-0426379-A2 | Substituted cyclobutenedione compounds | Beecham Group p.l.c. (GB) | 1991-05-08 | — | — | EP | disclosed |