SCHEMBL9360485

SCHEMBL9360485

COC(=O)C1=C(C)C2CCc3c(OC)c(C(C)C)cc(OC)c3C2(C)CC1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPAR1 Q92633 9/20 0.33
FDPS P14324 4/20 0.33
GGPS1 O95749 1/20 0.33
CYP3A4 P08684 8/20 0.32
ALDH1A1 P00352 3/20 0.32
MAPT P10636 3/20 0.32
AR P10275 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
SRD5A1 P18405 1/20 0.32
SRD5A2 P31213 1/20 0.32
BCL9 O00512 3/20 0.31
CTNNB1 P35222 3/20 0.31
HPGD P15428 2/20 0.31
MEN1 O00255 1/20 0.31
PTGES O14684 1/20 0.31
CYP2C9 P11712 1/20 0.31
PNLIP P16233 1/20 0.31
ALOX12 P18054 1/20 0.31
GSTO1 P78417 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9355660 0.91 CYP3A4 (0.33) LPAR1FDPSGGPS1CYP3A4ALDH1A1
SCHEMBL8855310 0.82 CYP3A4 (0.33) CYP3A4ALDH1A1MAPTARSMN1; SMN2
SCHEMBL29552237 0.81 FDPS (0.35) FDPSGGPS1CYP3A4ALDH1A1MAPT
SCHEMBL9359525 0.81 FDPS (0.35) FDPSGGPS1CYP3A4ALDH1A1MAPT
SCHEMBL8855173 0.80 CYP3A4 (0.31) CYP3A4ALDH1A1MAPTARSMN1; SMN2
SCHEMBL9360356 0.78 CYP3A4 (0.36) FDPSCYP3A4ALDH1A1MAPTSMN1; SMN2
SCHEMBL8855255 0.77 AKR1C3 (0.31) CYP3A4ALDH1A1MAPT
SCHEMBL8855332 0.73 CYP3A4 (0.54) FDPSGGPS1CYP3A4ALDH1A1MAPT
SCHEMBL29553299 0.73 CYP3A4 (0.43) LPAR1CYP3A4ALDH1A1MAPTAR
SCHEMBL29552419 0.73 CYP3A4 (0.43) LPAR1CYP3A4ALDH1A1MAPTAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0472733-B1 PHENANTHRENE DERIVATIVE OTSUKA PHARMA CO LTD (JP) 1994-12-28 EP disclosed
US-5192817-A Interleukin-1 inhibitors OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1993-03-09 US disclosed
EP-0472733-A1 PHENANTHRENE DERIVATIVE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1992-03-04 EP disclosed