Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT1 | P24752 | 1/20 | 1.00 |
| ▸ | PLK1 | P53350 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9365137 | 1.00 | ACAT1 (1.00) | ACAT1PLK1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL9361036 | 1.00 | ACAT1 (1.00) | ACAT1PLK1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL6940849 | 1.00 | ACAT1 (1.00) | ACAT1PLK1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL9365235 | 1.00 | ACAT1 (1.00) | ACAT1PLK1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL9361187 | 1.00 | ACAT1 (1.00) | ACAT1PLK1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL9361218 | 0.94 | ACAT1 (0.89) | ACAT1PLK1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL9365882 | 0.94 | ACAT1 (0.89) | ACAT1PLK1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL9365182 | 0.94 | ACAT1 (0.89) | ACAT1PLK1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL9365133 | 0.93 | ACAT1 (0.87) | ACAT1PLK1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL9362328 | 0.93 | ACAT1 (0.87) | ACAT1PLK1MAPK1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0424194-B1 | Benzanilide derivatives and their use as anti-atherosclerotic agents | RHONE POULENC SANTE (FR) | 1994-08-31 | — | — | EP | disclosed |
| US-5159114-A | Anticholesterol agents | RHONE-POULENC SANTE (FR) | 1992-10-27 | — | — | US | disclosed |
| EP-0424194-A2 | Benzanilide derivatives and their use as anti-atherosclerotic agents | RHONE-POULENC SANTE (FR) | 1991-04-24 | — | — | EP | disclosed |