Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | GLA | P06280 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.63 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.63 |
| ▸ | TUBB | P07437 | 3/20 | 0.63 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.63 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.63 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.63 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.63 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.63 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.63 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.63 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9363224 | 1.00 | ABCG2 (0.77) | ABCG2MEN1KMT2AHPGDLMNA | |
| SCHEMBL28802494 | 0.85 | TUBB4A (0.63) | MEN1KMT2AHPGDLMNAGLA | |
| SCHEMBL615819 | 0.82 | ABCG2 (0.88) | ABCG2MEN1KMT2ALMNATNFRSF1A | |
| SCHEMBL6659039 | 0.82 | ABCG2 (0.88) | ABCG2MEN1KMT2ALMNATNFRSF1A | |
| SCHEMBL6780730 | 0.82 | ABCG2 (0.88) | ABCG2TNFRSF1AABCB1TUBB1TUBB4A | |
| SCHEMBL10497922 | 0.82 | ABCG2 (0.88) | ABCG2LMNATNFRSF1AABCB1TUBB1 | |
| SCHEMBL6780724 | 0.82 | ABCG2 (0.88) | ABCG2TNFRSF1AABCB1TUBB1TUBB4A | |
| SCHEMBL15155080 | 0.81 | ABCG2 (0.86) | ABCG2TNFRSF1AABCB1TUBB1TUBB4A | |
| SCHEMBL15155082 | 0.81 | ABCG2 (0.86) | ABCG2TNFRSF1AABCB1TUBB1TUBB4A | |
| SCHEMBL29018483 | 0.81 | ABCG2 (0.86) | ABCG2LMNATNFRSF1AABCB1TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288794-B1 | Controlling the growth of tumor tissue with chalcone derivatives | MERRELL DOW PHARMA (US) | 1994-06-08 | — | — | EP | disclosed |
| EP-0286083-B1 | METHOD OF TREATING MULTIPLE SCLEROSIS WITH CHALCONE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-04 | — | — | EP | disclosed |
| EP-0287901-B1 | METHODS FOR TREATING GOUT WITH CHALCONE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4904697-A | Controlling the growth of certain tumor tissue with chalcone derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4863968-A | Methods of treating gout with chalcone derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4753965-A | INHIBITING DESTRUCTION OF MYELIN SHEATH; ANTIMITOTIC | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | disclosed |