Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL937384 | 0.89 | ALDH1A1 (0.51) | TP53MAPTNPC1RAB9APRKD1 | |
| SCHEMBL5209891 | 0.86 | NPC1 (0.57) | TP53MAPTNPC1RAB9APPARG | |
| SCHEMBL959372 | 0.85 | TP53 (0.65) | TP53MAPTNPC1RAB9APRKD1 | |
| SCHEMBL937517 | 0.85 | NPC1 (0.59) | TP53MAPTNPC1RAB9APRKD1 | |
| SCHEMBL12171803 | 0.84 | NPC1 (0.65) | TP53MAPTNPC1RAB9APTGS2 | |
| SCHEMBL1505201 | 0.84 | NPC1 (0.58) | TP53MAPTNPC1RAB9APPARG | |
| SCHEMBL12171384 | 0.84 | NPC1 (0.52) | TP53MAPTNPC1RAB9APRKD1 | |
| SCHEMBL960012 | 0.83 | NPC1 (0.52) | TP53MAPTNPC1RAB9APRKD1 | |
| SCHEMBL12171453 | 0.82 | TP53 (0.48) | TP53MAPTNPC1RAB9APRKD1 | |
| SCHEMBL12171582 | 0.82 | MAPT (0.53) | TP53MAPTNPC1RAB9APRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |