Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 15/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936255 | 0.89 | PRKD1 (0.73) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL6922501 | 0.87 | PRKD1 (0.80) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL6923037 | 0.87 | PRKD1 (0.70) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL1079502 | 0.85 | PRKD1 (0.70) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL960488 | 0.85 | PRKD1 (0.70) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL1053391 | 0.85 | PRKD1 (0.70) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL936143 | 0.84 | PRKD1 (0.54) | PRKD1ERN1BCHEACHEAPP | |
| SCHEMBL1083327 | 0.82 | PRKD1 (1.00) | PRKD1 | |
| SCHEMBL6923756 | 0.82 | PRKD1 (0.66) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL967019 | 0.81 | PRKD1 (1.00) | PRKD1ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |