Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 15/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1053391 | 0.89 | PRKD1 (0.70) | PRKD1MAPTBCHEACHEADORA3 | |
| SCHEMBL960488 | 0.89 | PRKD1 (0.70) | PRKD1MAPTBCHEACHEADORA3 | |
| SCHEMBL1024920 | 0.89 | PRKD1 (0.64) | PRKD1MAPTBCHEACHEADORA3 | |
| SCHEMBL1079502 | 0.87 | PRKD1 (0.70) | PRKD1MAPTBCHEACHEADORA3 | |
| SCHEMBL936788 | 0.83 | PRKD1 (0.65) | PRKD1MAPTADORA3ADORA2AADORA2B | |
| SCHEMBL6924052 | 0.83 | PRKD1 (0.69) | PRKD1BCHEACHEADORA3ADORA2A | |
| SCHEMBL6924065 | 0.83 | PRKD1 (0.64) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL936452 | 0.82 | PRKD1 (0.74) | PRKD1BCHEACHEADORA3ADORA2A | |
| SCHEMBL6922501 | 0.81 | PRKD1 (0.80) | PRKD1BCHEACHEADORA3ADORA2A | |
| SCHEMBL962069 | 0.81 | PRKD1 (0.66) | PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |