⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353472 | 0.85 | — | — | |
| SCHEMBL4135805 | 0.83 | THRB (0.32) | — | |
| SCHEMBL2648994 | 0.83 | — | — | |
| SCHEMBL5846069 | 0.82 | TSHR (0.30) | — | |
| SCHEMBL3328517 | 0.81 | HTT (0.32) | — | |
| SCHEMBL6827139 | 0.80 | — | — | |
| SCHEMBL9430665 | 0.79 | HSP90AB1 (0.37) | — | |
| SCHEMBL6121796 | 0.77 | — | — | |
| SCHEMBL8964624 | 0.76 | — | — | |
| SCHEMBL8684759 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456440-B1 | QUINOLINONE PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-19 | — | — | EP | disclosed |
| US-9017583-B2 | Photosensitive resin composition, and light blocking layer and liquid crystal display using the same | CHEIL INDUSTRIES INC. (KR) | 2015-04-28 | — | — | US | disclosed |
| EP-2003124-B1 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III | CHATHAM BIOTEC LTD (CA) | 2015-02-25 | — | — | EP | disclosed |
| US-20140175342-A1 | Photosensitive Resin Composition, and Light Blocking Layer and Liquid Crystal Display Using the Same | CHEIL INDUSTRIES INC. (KR) | 2014-06-26 | — | — | US | disclosed |
| US-8680116-B2 | Quinolinone PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-03-25 | — | — | US | disclosed |
| EP-2456440-A1 | QUINOLINONE PDE2 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-05-30 | — | — | EP | disclosed |
| US-20120115885-A1 | Quinolinone PDE2 Inhibitors | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| WO-2011023722-A1 | NOVEL QUINOXALINONE HEPCIDIN ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2011-03-03 | — | — | WO | disclosed |
| EP-1831184-B1 | PYRAZINES AND PYRIDINES AND DERIVATIVES THEREOF AS THERAPEUTIC COMPOUNDS | WELLCOME TRUST LTD (GB) | 2011-02-09 | — | — | EP | disclosed |
| WO-2011011312-A1 | QUINOLINONE PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-01-27 | — | — | WO | disclosed |
| WO-2006067466-A2 | PYRAZINES AND PYRIDINES AND DERIVATIVES THEREOF AS THERAPEUTIC COMPOUNDS | THE WELLCOME TRUST LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
| EP-1562927-A2 | THIO-ANALOGUES OF PACLITAXEL AND INTERMEDIATES THEREOF | Phytogen Life Sciences Inc. (CA) | 2005-08-17 | — | — | EP | disclosed |
| US-20050143408-A1 | Aporphine esters and their use in therapy | AXON BIOCHEMICALS B.V. (NL) | 2005-06-30 | — | — | US | disclosed |
| WO-2005044811-A2 | SEMI-SYNTHESIS OF TAXANE INTERMEDIATES FROM 9-DIHYDRO-13-ACETYLBACCATIN III | PHYTOGEN LIFE SCIENCES INC. (CA) | 2005-05-19 | — | — | WO | disclosed |
| US-20050101789-A1 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III | PHYTOGEN LIFE SCIENCES INC. (CA) | 2005-05-12 | — | — | US | disclosed |
| US-20050009831-A1 | Pyrrolo[1,2-a]pyrazine-8-carboxamides are JNK inhibitors, useful as anticarcinogenic agents | AVENTIS PHARMA S.A, (FR) | 2005-01-13 | — | — | US | disclosed |
| EP-1436291-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | Aventis Pharma S.A. (FR) | 2004-07-14 | — | — | EP | disclosed |
| US-20040132991-A1 | Novel taxanes and methods related to use and preparation thereof | PHYTOGEN LIFE SCIENCES INC. (CA) | 2004-07-08 | — | — | US | disclosed |
| WO-2004033442-A2 | NOVEL TAXANES AND METHODS RELATED TO USE AND PREPARATION THEREOF | CHATHAM BIOTEC LTD. (CA) | 2004-04-22 | — | — | WO | disclosed |
| WO-2003024967-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2003-03-27 | — | — | WO | disclosed |