Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 7/20 | 0.49 |
| ▸ | PNP | P00491 | 5/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | HBB | P68871 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TK1 | P04183 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887437 | 0.90 | HPRT1 (0.51) | HPRT1PNPBLMHBBUSP2 | |
| SCHEMBL9365016 | 0.90 | HPRT1 (0.51) | HPRT1PNPBLMHBBUSP2 | |
| SCHEMBL8887441 | 0.90 | HPRT1 (0.51) | HPRT1PNPBLMHBBUSP2 | |
| SCHEMBL9364387 | 0.84 | PNP (0.52) | HPRT1PNPBLMHBBUSP2 | |
| SCHEMBL9364800 | 0.83 | TK1 (0.57) | HPRT1PNPBLMHBBUSP2 | |
| SCHEMBL9369529 | 0.82 | TK1 (0.56) | HPRT1PNPBLMHBBUSP2 | |
| SCHEMBL9369416 | 0.82 | TK1 (0.56) | HPRT1PNPBLMHBBUSP2 | |
| SCHEMBL9367676 | 0.81 | TK1 (0.57) | HPRT1PNPBLMHBBUSP2 | |
| SCHEMBL10678497 | 0.79 | PNP (0.58) | HPRT1PNPBLMHBBUSP2 | |
| SCHEMBL9369448 | 0.79 | TK1 (0.59) | HPRT1PNPBLMHBBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291229-B1 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO INC (US) | 1994-04-13 | — | — | EP | claimed |
| EP-0291229-A2 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO. INC. (US) | 1988-11-17 | — | — | EP | claimed |
| US-4782062-A | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | claimed |
| EP-0291229-B1 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO INC (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0291229-A2 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO. INC. (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4782062-A | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | disclosed |