Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939914 | 0.88 | LCK (0.65) | POLBMEN1MAPTKMT2ALCK | |
| SCHEMBL17560534 | 0.86 | POLB (0.48) | POLBMEN1MAPTKMT2ALCK | |
| SCHEMBL4138153 | 0.85 | ALDH1A1 (0.46) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL26353609 | 0.83 | ALDH1A1 (0.47) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL522262 | 0.83 | HTT (0.64) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL14915504 | 0.81 | LCK (0.65) | POLBMEN1MAPTKMT2ALCK | |
| SCHEMBL26352343 | 0.81 | MAPT (0.49) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL13835715 | 0.81 | ALDH1A1 (0.43) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL15006078 | 0.81 | ALDH1A1 (0.44) | POLBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL23163264 | 0.80 | LCK (0.46) | POLBMEN1MAPTKMT2ALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377112-B1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-08-24 | — | — | EP | disclosed |
| US-5061706-A | 2,3-QUINOXALINEDIONES FOR USE AS NEUROLEPTICS | NOVO NORDISK A/S (DK) | 1991-10-29 | — | — | US | disclosed |
| EP-0377112-A1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1990-07-11 | — | — | EP | disclosed |