Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13835525 | 0.82 | TDP1 (0.53) | TDP1KDM4EPOLBCTDSP1L3MBTL1 | |
| SCHEMBL14495072 | 0.81 | KDM4E (0.51) | TDP1KDM4EPOLBCTDSP1L3MBTL1 | |
| SCHEMBL6552022 | 0.80 | MAPT (0.54) | TDP1POLBL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL10659582 | 0.79 | TDP1 (0.54) | TDP1KDM4EPOLBCTDSP1L3MBTL1 | |
| SCHEMBL7840604 | 0.79 | KMT2A (0.40) | TDP1POLBPKMALDH1A1MEN1 | |
| SCHEMBL4869351 | 0.77 | TDP1 (0.50) | TDP1KDM4EPOLBCTDSP1L3MBTL1 | |
| SCHEMBL28253250 | 0.76 | TDP1 (0.49) | TDP1KDM4EPOLBCTDSP1L3MBTL1 | |
| SCHEMBL11102155 | 0.76 | MAPT (0.54) | TDP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10912275 | 0.76 | TDP1 (0.72) | TDP1KDM4EPOLBCTDSP1L3MBTL1 | |
| SCHEMBL14495075 | 0.76 | MAPT (0.51) | TDP1KDM4EALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377112-B1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-08-24 | — | — | EP | disclosed |
| US-5061706-A | 2,3-QUINOXALINEDIONES FOR USE AS NEUROLEPTICS | NOVO NORDISK A/S (DK) | 1991-10-29 | — | — | US | disclosed |