Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 11/20 | 0.80 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923883 | 0.89 | PRKD1 (1.00) | PRKD1PRKD3PRKD2JAK2ROCK2 | |
| SCHEMBL936937 | 0.88 | PRKD1 (0.81) | PRKD1PRKD3PRKD2HIF1AUSP30 | |
| SCHEMBL936935 | 0.88 | PRKD1 (0.81) | PRKD1PRKD3PRKD2HIF1AUSP30 | |
| SCHEMBL937419 | 0.86 | PRKD1 (0.60) | PRKD1PRKD3PRKD2HIF1AHDAC1 | |
| SCHEMBL6923188 | 0.85 | PRKD1 (0.62) | PRKD1PRKD3PRKD2HIF1ANPC1 | |
| SCHEMBL6923240 | 0.85 | PRKD1 (0.74) | PRKD1PRKD3PRKD2JAK2ROCK2 | |
| SCHEMBL936361 | 0.83 | PRKD1 (0.67) | PRKD1PRKD3PRKD2JAK2ROCK2 | |
| SCHEMBL6923810 | 0.82 | PRKD1 (0.66) | PRKD1PRKD3PRKD2NPC1RAB9A | |
| SCHEMBL6923579 | 0.82 | PRKD1 (0.65) | PRKD1PRKD3PRKD2ROCK2 | |
| SCHEMBL938116 | 0.82 | PRKD1 (0.69) | PRKD1PRKD3PRKD2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |