Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 9/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923188 | 0.90 | PRKD1 (0.62) | PRKD1PRKD3PRKD2HIF1AMAP4K4 | |
| SCHEMBL936484 | 0.86 | PRKD1 (0.80) | PRKD1PRKD3PRKD2HIF1AHDAC1 | |
| SCHEMBL936935 | 0.84 | PRKD1 (0.81) | PRKD1PRKD3PRKD2HIF1AMAP4K4 | |
| SCHEMBL936937 | 0.84 | PRKD1 (0.81) | PRKD1PRKD3PRKD2HIF1AMAP4K4 | |
| SCHEMBL6923210 | 0.77 | NPC1 (0.50) | PRKD1PPARGPPARAS1PR1S1PR3 | |
| SCHEMBL5206252 | 0.75 | NPC1 (0.66) | PPARGPPARA | |
| SCHEMBL6924074 | 0.75 | PRKD1 (1.00) | PRKD1PRKD3PRKD2PPARGPPARA | |
| SCHEMBL6923883 | 0.73 | PRKD1 (1.00) | PRKD1PRKD3PRKD2HDAC1ATM | |
| SCHEMBL957155 | 0.73 | PTPN1 (0.61) | PPARGPPARA | |
| SCHEMBL17336802 | 0.73 | NPC1 (0.62) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |