Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.66 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.66 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | RHOC | P08134 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.59 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.59 |
| ▸ | PDE6D | O43924 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9906 | 0.90 | HMGCR (0.72) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 | |
| SCHEMBL14424499 | 0.85 | SLCO1B1 (0.78) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 | |
| SCHEMBL14414151 | 0.85 | SLCO1B1 (0.78) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 | |
| SCHEMBL12210219 | 0.83 | SLCO1B1 (0.75) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 | |
| SCHEMBL10018612 | 0.83 | SLCO1B1 (0.75) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 | |
| SCHEMBL12073345 | 0.82 | HMGCR (0.72) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 | |
| SCHEMBL5607440 | 0.82 | SLCO1B1 (0.71) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 | |
| SCHEMBL5607435 | 0.82 | SLCO1B1 (0.79) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 | |
| SCHEMBL14414147 | 0.82 | SLCO1B1 (0.79) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 | |
| SCHEMBL5808035 | 0.81 | SLCO1B1 (0.66) | HMGCRSLCO1B1ABCB1ABCC2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330172-B1 | Improved process for trans-6-[2-(substituted-pyrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER LAMBERT CO (US) | 1994-08-10 | — | — | EP | disclosed |
| US-5280126-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1994-01-18 | — | — | US | disclosed |
| US-5245047-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| US-5216174-A | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT CO. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5124482-A | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |
| US-5003080-A | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1991-03-26 | — | — | US | disclosed |
| EP-0330172-A2 | Improved process for trans-6-[2-(substituted-pyrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |