Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.72 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | RHOC | P08134 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.72 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.72 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.70 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.70 |
| ▸ | PDE6D | O43924 | 4/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.61 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9365103 | 0.91 | HMGCR (0.70) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL12192335 | 0.90 | HMGCR (0.77) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL13118089 | 0.87 | HMGCR (0.78) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL13118085 | 0.87 | HMGCR (0.78) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL12073345 | 0.87 | HMGCR (0.72) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL5809239 | 0.86 | HMGCR (0.71) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL13734511 | 0.86 | HMGCR (0.76) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL12283340 | 0.86 | HMGCR (0.85) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL3533994 | 0.86 | HMGCR (0.91) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL3535164 | 0.86 | HMGCR (0.91) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330172-B1 | Improved process for trans-6-[2-(substituted-pyrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER LAMBERT CO (US) | 1994-08-10 | — | — | EP | disclosed |
| US-5280126-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1994-01-18 | — | — | US | disclosed |
| US-5245047-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| US-5216174-A | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT CO. (US) | 1993-06-01 | — | — | US | disclosed |
| US-5124482-A | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |
| US-5097045-A | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| US-5003080-A | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1991-03-26 | — | — | US | disclosed |
| EP-0330172-A2 | Improved process for trans-6-[2-(substituted-pyrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |