Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | PPM1B | O75688 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10514784 | 1.00 | TSHR (0.45) | TSHRTAAR1LMNAAKT1AGTR2 | |
| SCHEMBL10517771 | 1.00 | TSHR (0.45) | TSHRTAAR1LMNAAKT1AGTR2 | |
| SCHEMBL9369568 | 1.00 | TSHR (0.45) | TSHRTAAR1LMNAAKT1AGTR2 | |
| SCHEMBL9416326 | 0.88 | PDE4D (0.41) | TSHRTAAR1LMNAAKT1AGTR2 | |
| SCHEMBL9416327 | 0.88 | PDE4D (0.41) | TSHRTAAR1LMNAAKT1AGTR2 | |
| SCHEMBL9416279 | 0.86 | BCHE (0.47) | TSHRTAAR1LMNAAKT1PDE4D | |
| SCHEMBL9416282 | 0.86 | BCHE (0.47) | TSHRTAAR1LMNAAKT1PDE4D | |
| SCHEMBL9416300 | 0.85 | TSHR (0.44) | TSHRTAAR1LMNAAKT1AGTR2 | |
| SCHEMBL14514260 | 0.85 | TSHR (0.44) | TSHRTAAR1LMNAAKT1AGTR2 | |
| SCHEMBL15369588 | 0.78 | TSHR (0.40) | TSHRTAAR1LMNAAKT1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322854-B1 | Purinyl cyclobutanes | SQUIBB & SONS INC (US) | 1994-07-13 | — | — | EP | disclosed |
| US-4918075-A | Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents | E. R. SQUIBB & SONS, INC. (US) | 1990-04-17 | — | — | US | disclosed |
| US-4855466-A | Purinyl cyclobutanes | E. R. SQUIBB & SONS, INC. (US) | 1989-08-08 | — | — | US | disclosed |
| EP-0322854-A1 | Purinyl cyclobutanes | E.R. Squibb & Sons, Inc. (US) | 1989-07-05 | — | — | EP | disclosed |