Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1252918 | 0.85 | KMT2A (0.64) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL19246201 | 0.84 | HPGD (0.64) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL17443355 | 0.82 | NPC1 (0.48) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL10341802 | 0.81 | NPC1 (0.58) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9700935 | 0.81 | KMT2A (0.58) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL20511418 | 0.81 | MEN1 (0.62) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL20495063 | 0.78 | MEN1 (0.59) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3957352 | 0.78 | CYP2C19 (0.60) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL513780 | 0.78 | PTPN1 (0.61) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21545834 | 0.78 | NPC1 (0.59) | ALDH1A1HPGDMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373891-B1 | Anti-tumour agents | ICI PLC (GB) | 1994-11-02 | — | — | EP | claimed |
| EP-0373891-A2 | Anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-20 | — | — | EP | claimed |
| EP-0373891-B1 | Anti-tumour agents | ICI PLC (GB) | 1994-11-02 | — | — | EP | disclosed |
| EP-0373891-A2 | Anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-20 | — | — | EP | disclosed |