Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
| ▸ | RELA | Q04206 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9366265 | 1.00 | GRIA2 (0.37) | GRIA2RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL9366241 | 0.99 | RAB9A (0.38) | GRIA2RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL9366234 | 0.99 | RAB9A (0.38) | GRIA2RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL9366591 | 0.96 | GRIA2 (0.38) | GRIA2RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL9366580 | 0.96 | GRIA2 (0.38) | GRIA2RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL9366634 | 0.92 | GRIA2 (0.39) | GRIA2RAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9366626 | 0.92 | GRIA2 (0.39) | GRIA2RAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9365143 | 0.88 | KDM1A (0.45) | RAB9ANPC1SMN1; SMN2MAPTSTAT3 | |
| SCHEMBL9365134 | 0.88 | KDM1A (0.45) | RAB9ANPC1SMN1; SMN2MAPTSTAT3 | |
| SCHEMBL9366251 | 0.88 | GRM2 (0.39) | RAB9ANPC1SMN1; SMN2MAPTSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433835-B1 | Dioxanylpyridines | HOFFMANN LA ROCHE (CH) | 1994-05-18 | — | — | EP | disclosed |
| US-5160661-A | DIOXANYLPYRIDINE | HOFFMANN-LA ROCHE INC. (US) | 1992-11-03 | — | — | US | disclosed |
| EP-0433835-A2 | Dioxanylpyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |