Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.61 |
| ▸ | DRD2 | P14416 | 10/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | GOT1 | P17174 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9367513 | 0.90 | HTR2A (0.61) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL9366449 | 0.89 | HTR2A (0.70) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL9366415 | 0.89 | HTR2A (0.70) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6219065 | 0.89 | HTR2A (0.70) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Hydrochloric Acid SCHEMBL9366488 | 0.87 | HTR2A (0.68) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Hydrochloric Acid SCHEMBL9366678 | 0.87 | HTR2A (0.68) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Hydrochloric Acid SCHEMBL9367301 | 0.87 | HTR2A (0.68) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL9366269 | 0.85 | HTR2A (0.61) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6259705 | 0.84 | HTR2A (0.65) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6261335 | 0.84 | HTR2A (0.65) | HTR2ADRD2HTR1AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409435-B1 | Heteroaryl piperazine antipsychotic agents | PFIZER (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5350747-A | Heteroaryl piperazine antipsychotic agents | PFIZER INC (US) | 1994-09-27 | — | — | US | disclosed |
| WO-1991000863-A1 | HETEROARYL PIPERAZINE ANTIPSYCHOTIC AGENTS | PFIZER INC. (US) | 1991-01-24 | — | — | WO | disclosed |
| EP-0409435-A1 | Heteroaryl piperazine antipsychotic agents | PFIZER INC. (US) | 1991-01-23 | — | — | EP | disclosed |