Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 11/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9731557 | 1.00 | GRIA2 (0.39) | GRIA2KDM1ANPC1RXFP1MEN1 | |
| SCHEMBL9731554 | 1.00 | GRIA2 (0.39) | GRIA2KDM1ANPC1RXFP1MEN1 | |
| SCHEMBL9366345 | 1.00 | GRIA2 (0.39) | GRIA2KDM1ANPC1RXFP1MEN1 | |
| SCHEMBL9365368 | 0.88 | KDM1A (0.48) | GRIA2KDM1AMAOB | |
| SCHEMBL9730803 | 0.88 | KDM1A (0.48) | GRIA2KDM1AMAOB | |
| SCHEMBL9730800 | 0.88 | KDM1A (0.48) | GRIA2KDM1AMAOB | |
| SCHEMBL9365360 | 0.88 | KDM1A (0.48) | GRIA2KDM1AMAOB | |
| SCHEMBL9732702 | 0.87 | KDM1A (0.41) | KDM1ANPC1MAOBCYP11B1CYP11B2 | |
| SCHEMBL9366647 | 0.87 | KDM1A (0.41) | KDM1ANPC1MAOBCYP11B1CYP11B2 | |
| SCHEMBL9732698 | 0.87 | KDM1A (0.41) | KDM1ANPC1MAOBCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433835-B1 | Dioxanylpyridines | HOFFMANN LA ROCHE (CH) | 1994-05-18 | — | — | EP | disclosed |
| US-5160661-A | DIOXANYLPYRIDINE | HOFFMANN-LA ROCHE INC. (US) | 1992-11-03 | — | — | US | disclosed |
| EP-0433835-A2 | Dioxanylpyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |