Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | PLAT | P00750 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8742185 | 0.99 | PPARG (0.46) | PPARGPPARAKDM4EALDH1A1GAA | |
| SCHEMBL9618625 | 0.91 | PPARG (0.45) | PPARGPPARAKDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL9423232 | 0.90 | PPARG (0.44) | PPARGPPARAKDM4EALDH1A1GAA | |
| SCHEMBL6168598 | 0.82 | PPARG (0.42) | PPARGPPARAKDM4EMAPTMEN1 | |
| SCHEMBL9366795 | 0.82 | PPARG (0.45) | PPARGPPARAKDM4EALDH1A1GAA | |
| SCHEMBL9366389 | 0.81 | PPARG (0.53) | PPARGPPARAKDM4EALDH1A1GAA | |
| SCHEMBL4588655 | 0.81 | PPARG (0.51) | PPARGPPARAKDM4EMAPTMEN1 | |
| SCHEMBL4589097 | 0.81 | PPARG (0.51) | PPARGPPARAKDM4EMAPTMEN1 | |
| SCHEMBL4589201 | 0.81 | PPARG (0.51) | PPARGPPARAKDM4EMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL8742253 | 0.80 | PPARG (0.53) | PPARGPPARAKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458697-B1 | N-substituted trifluoromethylphenyl tetrahydropyridines, process for their preparation, intermediates and pharmaceutical preparations containing them | SANOFI ELF (FR) | 1994-07-27 | — | — | EP | disclosed |
| EP-0458697-A1 | N-substituted trifluoromethylphenyl tetrahydropyridines, process for their preparation, intermediates and pharmaceutical preparations containing them | ELF SANOFI (FR) | 1991-11-27 | — | — | EP | disclosed |