Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.60 |
| ▸ | HTR7 | P34969 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 8/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.57 |
| ▸ | DRD2 | P14416 | 7/20 | 0.57 |
| ▸ | HTR6 | P50406 | 2/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.57 |
| ▸ | HTR3B | O95264 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | GOT1 | P17174 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9367637 | 0.89 | HTR1A (0.60) | HTR1AHTR7HTR2AKCNH2DRD2 | |
| SCHEMBL9367264 | 0.86 | HTR1A (0.58) | HTR1AHTR7HTR2AKCNH2DRD2 | |
| SCHEMBL5678980 | 0.84 | HTR1A (0.61) | HTR1AHTR7HTR2AKCNH2DRD2 | |
| SCHEMBL6745326 | 0.84 | HTR1A (0.56) | HTR1AHTR7HTR2AKCNH2DRD2 | |
| SCHEMBL5767939 | 0.83 | HTR1A (0.62) | HTR1AHTR7HTR2AKCNH2DRD2 | |
| SCHEMBL4885467 | 0.83 | HTR1A (0.74) | HTR1AHTR7HTR2AKCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL4891136 | 0.83 | HTR1A (0.59) | HTR1AHTR7HTR2AKCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL7099059 | 0.82 | KCNH2 (0.73) | HTR1AHTR7HTR2AKCNH2DRD2 | |
| SCHEMBL9367026 | 0.82 | HTR2A (0.69) | HTR1AHTR7HTR2AKCNH2DRD2 | |
| SCHEMBL6790516 | 0.82 | HTR1A (0.60) | HTR1AHTR7HTR2AKCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409435-B1 | Heteroaryl piperazine antipsychotic agents | PFIZER (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5350747-A | Heteroaryl piperazine antipsychotic agents | PFIZER INC (US) | 1994-09-27 | — | — | US | disclosed |
| EP-0409435-A1 | Heteroaryl piperazine antipsychotic agents | PFIZER INC. (US) | 1991-01-23 | — | — | EP | disclosed |