Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.61 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376550 | 0.93 | MEN1 (0.72) | HSD17B10MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL10195010 | 0.88 | HSD17B10 (0.68) | HSD17B10DRD2ABCG2MCHR2MCHR1 | |
| SCHEMBL10195728 | 0.88 | HSD17B10 (0.68) | HSD17B10DRD2ABCG2MCHR2MCHR1 | |
| SCHEMBL10195730 | 0.88 | HSD17B10 (0.68) | HSD17B10DRD2ABCG2MCHR2MCHR1 | |
| SCHEMBL4283979 | 0.87 | HSD17B10 (0.70) | HSD17B10SMN1; SMN2DRD2ABCG2MCHR2 | |
| SCHEMBL11919266 | 0.87 | DRD2 (0.67) | HSD17B10DRD2ABCG2MCHR2MCHR1 | |
| SCHEMBL4341169 | 0.87 | MCHR1 (0.69) | HSD17B10KMT2ASMN1; SMN2DRD2ABCG2 | |
| SCHEMBL18376617 | 0.86 | ABCG2 (0.60) | HSD17B10MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL15317635 | 0.86 | HSD17B10 (0.65) | HSD17B10SMN1; SMN2DRD2ABCG2MCHR2 | |
| SCHEMBL11916163 | 0.86 | HSD17B10 (0.65) | HSD17B10SMN1; SMN2DRD2ABCG2MCHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290377-B1 | Substituted 4-[1H-Imidazol-1-yl] benzamides as antiarrhythmic agents | SCHERING AG (DE) | 1994-03-02 | — | — | EP | disclosed |
| US-4804662-A | Substituted 4-(1H-imidazol-1-yl)benzamides as antiarrhythmic agents | SCHERING A.G. (DE) | 1989-02-14 | — | — | US | disclosed |
| EP-0290377-A1 | Substituted 4-[1H-Imidazol-1-yl] benzamides as antiarrhythmic agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-11-09 | — | — | EP | disclosed |