Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 15/20 | 0.56 |
| ▸ | BRPF1 | P55201 | 5/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | BRD1 | O95696 | 2/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.35 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371531 | 0.89 | ALOX5 (0.58) | ALOX5BRPF1BRD4BRD1BRD9 | |
| SCHEMBL9367188 | 0.83 | ALOX5 (0.51) | ALOX5 | |
| SCHEMBL9219847 | 0.80 | ALOX5 (0.79) | ALOX5 | |
| SCHEMBL9216159 | 0.80 | ALOX5 (0.79) | ALOX5 | |
| SCHEMBL9098432 | 0.79 | ALOX5 (0.42) | ALOX5BRD4 | |
| SCHEMBL9371545 | 0.77 | ALOX5 (0.46) | ALOX5BRPF1BRD4BRD1BRD9 | |
| SCHEMBL9367578 | 0.76 | ALOX5 (0.72) | ALOX5BRPF1BRD4BRD1BRD9 | |
| SCHEMBL9076299 | 0.76 | ALOX5 (0.30) | ALOX5 | |
| SCHEMBL9050113 | 0.76 | ALOX5 (0.30) | ALOX5 | |
| SCHEMBL9076298 | 0.76 | ALOX5 (0.30) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420511-B1 | Heterocyclic derivatives | ICI PLC (GB) | 1994-08-17 | — | — | EP | disclosed |
| US-5302594-A | Antiinflammatory agents; antiallergenic agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-12 | — | — | US | disclosed |
| WO-1993016073-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-19 | — | — | WO | disclosed |
| US-5221677-A | For treating diseases mediated by leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-22 | — | — | US | disclosed |