Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 19/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9368681 | 0.85 | ALOX5 (0.35) | ALOX5PTGS2PTGS1 | |
| SCHEMBL9367759 | 0.82 | ALOX5 (0.39) | ALOX5 | |
| SCHEMBL9259112 | 0.82 | ALOX5 (0.43) | ALOX5 | |
| SCHEMBL9250218 | 0.81 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL9254294 | 0.81 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL9367706 | 0.81 | ALOX5 (0.50) | ALOX5PTGS2PTGS1 | |
| SCHEMBL9258570 | 0.80 | ALOX5 (0.45) | ALOX5PTGS1 | |
| SCHEMBL9029002 | 0.78 | ALOX5 (0.70) | ALOX5PTGS2PTGS1 | |
| SCHEMBL9440485 | 0.77 | ALOX5 (0.44) | ALOX5PTGS2PTGS1 | |
| SCHEMBL7481034 | 0.76 | ALOX5 (0.53) | ALOX5PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420511-B1 | Heterocyclic derivatives | ICI PLC (GB) | 1994-08-17 | — | — | EP | disclosed |
| US-5302594-A | Antiinflammatory agents; antiallergenic agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-12 | — | — | US | disclosed |
| US-5258399-A | 5-lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-11-02 | — | — | US | disclosed |
| US-5236948-A | Lipoxygenase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5221677-A | For treating diseases mediated by leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-22 | — | — | US | disclosed |
| EP-0495594-A1 | Sulphonamide derivatives | ZENECA LIMITED (GB) | 1992-07-22 | — | — | EP | disclosed |
| EP-0420511-A2 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-03 | — | — | EP | disclosed |