Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469991 | 0.84 | MEN1 (0.33) | MMEMEN1GAAKMT2ACYP2C19 | |
| SCHEMBL5702723 | 0.82 | MME (0.41) | MMEMEN1GAAKMT2ACYP2C19 | |
| SCHEMBL5702726 | 0.82 | MME (0.41) | MMEMEN1GAAKMT2ACYP2C19 | |
| SCHEMBL9337097 | 0.81 | CYP2C19 (0.36) | MMECYP2C19 | |
| SCHEMBL9341047 | 0.81 | CYP2C19 (0.36) | MMECYP2C19 | |
| SCHEMBL7368344 | 0.81 | CYP2C19 (0.36) | MMECYP2C19 | |
| SCHEMBL7296981 | 0.80 | CYP2C19 (0.35) | MMECYP2C19 | |
| SCHEMBL9363228 | 0.80 | MME (0.33) | MMECYP2C19 | |
| SCHEMBL9367713 | 0.79 | — | — | |
| SCHEMBL7131535 | 0.79 | MME (0.37) | MMECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594588-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1994-05-04 | — | — | EP | disclosed |
| WO-1991013054-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | PFIZER LIMITED (GB) | 1991-09-05 | — | — | WO | disclosed |