Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 11/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9442376 | 0.84 | POLB (0.58) | DBHALDH1A1POLB | |
| SCHEMBL9442377 | 0.81 | POLB (0.51) | DBHALDH1A1POLB | |
| SCHEMBL9442375 | 0.72 | DBH (0.57) | DBHALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL9442398 | 0.72 | DBH (0.50) | DBHALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL11079680 | 0.72 | DBH (1.00) | DBHALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL9442384 | 0.71 | DBH (0.42) | DBHALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL9442394 | 0.71 | DBH (0.42) | DBHALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL9371273 | 0.70 | DBH (0.60) | DBHALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL9368556 | 0.70 | DBH (0.56) | DBHALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL10556159 | 0.69 | DBH (0.46) | DBHALDH1A1CYP1A2POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0244803-B1 | Novel dopamine beta hydroxylase inhibitors | MERRELL DOW PHARMA (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5198457-A | Treatment of hyperthyroidism with 1,3-dihydro-1[2-(2-thienyl)alkyl]-2H-imidazole-2-thiones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5189052-A | Hypotensive agent | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| US-5057613-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS (US) | 1991-10-15 | — | — | US | disclosed |
| US-4810800-A | HYPOTENSIVE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0244803-A2 | Novel dopamine beta hydroxylase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-11-11 | — | — | EP | disclosed |