Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 7/20 | 0.54 |
| ▸ | NOS1 | P29475 | 5/20 | 0.35 |
| ▸ | PNP | P00491 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PAH | P00439 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364811 | 0.95 | HPRT1 (0.53) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9367685 | 0.95 | HPRT1 (0.53) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9369536 | 0.94 | HPRT1 (0.52) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9369424 | 0.94 | HPRT1 (0.52) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL7515747 | 0.90 | HPRT1 (0.54) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL8447171 | 0.83 | HPRT1 (0.57) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL10836058 | 0.81 | HPRT1 (0.56) | HPRT1NOS1PNPKMT2A | |
| SCHEMBL9739844 | 0.81 | HPRT1 (0.60) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9365027 | 0.80 | HPRT1 (0.48) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9308669 | 0.80 | HPRT1 (0.41) | HPRT1NOS1PNPNOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291229-B1 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO INC (US) | 1994-04-13 | — | — | EP | claimed |
| EP-0291229-A2 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO. INC. (US) | 1988-11-17 | — | — | EP | claimed |
| US-4782062-A | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | claimed |
| EP-0291229-B1 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO INC (US) | 1994-04-13 | — | — | EP | disclosed |
| US-5246931-A | Triazine-substituted cyclobutane derivatives; viricides; side effect reduction | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-09-21 | — | — | US | disclosed |
| US-5153352-A | Viricides and antitumor agent | BRISTOL-MYERS SQUIBB COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| US-4988703-A | Viricides of hydroxyethylcyclopropylguanine | ABBOTT LABORATORIES (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0366059-A2 | Carbocyclic nucleoside analogs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-05-02 | — | — | EP | disclosed |
| EP-0291229-A2 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO. INC. (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4782062-A | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | disclosed |