Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 8/20 | 0.52 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | PNP | P00491 | 4/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369424 | 1.00 | HPRT1 (0.52) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9364811 | 0.99 | HPRT1 (0.53) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9367685 | 0.96 | HPRT1 (0.53) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9369454 | 0.94 | HPRT1 (0.54) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL7515747 | 0.87 | HPRT1 (0.54) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9365027 | 0.84 | HPRT1 (0.48) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9364661 | 0.82 | HPRT1 (0.46) | HPRT1NOS1 | |
| SCHEMBL8447171 | 0.80 | HPRT1 (0.57) | HPRT1NOS1PNPNOS3NOS2 | |
| SCHEMBL9364393 | 0.79 | HPRT1 (0.44) | HPRT1NOS1 | |
| SCHEMBL10836058 | 0.79 | HPRT1 (0.56) | HPRT1NOS1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291229-B1 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO INC (US) | 1994-04-13 | — | — | EP | claimed |
| EP-0291229-A2 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO. INC. (US) | 1988-11-17 | — | — | EP | claimed |
| US-4782062-A | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | claimed |
| EP-0291229-B1 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO INC (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0291229-A2 | 9(2-(hydroxymethyl) cycloalkylmethyl)guanines | MERCK & CO. INC. (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4782062-A | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | disclosed |