Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.46 |
| ▸ | PIK3C2G | O75747 | 6/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.40 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369457 | 0.85 | CYP3A4 (0.47) | PIK3CDPIK3C2GPIK3CGBRD4IDO1 | |
| SCHEMBL10205375 | 0.81 | CA1 (0.50) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL9369940 | 0.79 | PIK3CD (0.50) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL22663660 | 0.76 | PIK3CD (0.58) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL8101449 | 0.76 | MYC (0.40) | GAANPC1SMN1; SMN2 | |
| SCHEMBL8790761 | 0.75 | TTR (0.50) | BRD4MAPK7TTRCES1ALDH1A1 | |
| SCHEMBL9368507 | 0.75 | ALDH1A1 (0.54) | LRRK2GAANPC1ALDH1A1CYP1A2 | |
| SCHEMBL8791033 | 0.75 | BRD4 (0.41) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL19457452 | 0.74 | PIK3CD (0.56) | PIK3CDPIK3C2GPIK3CGAURKAAURKB | |
| SCHEMBL20875242 | 0.74 | PIK3CD (0.59) | PIK3CDPIK3C2GPIK3CGAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393530-B1 | 5,11-dihydro-6H-pyrido[2,3,-b][1,4]benzodiazepin-6-ones and -thiones and their use in the prevention or treatment of AIDS | BOEHRINGER INGELHEIM PHARMA (US) | 1994-12-28 | — | — | EP | claimed |
| EP-0623112-A1 | 4-ARYL-3-(HETEROARYLUREIDO)-1,2-DIHYDRO-2-OXO-QUINOLINE DERIVATIVES AS ANTIHYPERCHOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS | PFIZER INC. (US) | 1994-11-09 | — | — | EP | claimed |
| EP-0393530-B1 | 5,11-dihydro-6H-pyrido[2,3,-b][1,4]benzodiazepin-6-ones and -thiones and their use in the prevention or treatment of AIDS | BOEHRINGER INGELHEIM PHARMA (US) | 1994-12-28 | — | — | EP | disclosed |
| US-5087625-A | Pyridodiazepines and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1992-02-11 | — | — | US | disclosed |
| EP-0393530-A1 | 5,11-dihydro-6H-pyrido[2,3,-b][1,4]benzodiazepin-6-ones and -thiones and their use in the prevention or treatment of AIDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1990-10-24 | — | — | EP | disclosed |