Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369814 | 0.87 | CHRM2 (0.54) | CHRM2CHRM1 | |
| SCHEMBL9370449 | 0.83 | CHRM2 (0.65) | CHRM2CHRM1 | |
| Oxadiazole SCHEMBL9369455 | 0.79 | CHRM2 (1.00) | CHRM2CHRM1KCNH2 | |
| SCHEMBL9375472 | 0.77 | CHRM2 (0.54) | CHRM2CHRM1 | |
| SCHEMBL8825098 | 0.77 | CHRM2 (0.85) | CHRM2CHRM1KCNH2 | |
| SCHEMBL9368693 | 0.74 | CHRM2 (0.83) | CHRM2CHRM1 | |
| SCHEMBL9152227 | 0.72 | CHRM2 (0.35) | CHRM2CHRM1 | |
| SCHEMBL8873427 | 0.71 | CHRM2 (0.61) | CHRM2CHRM1KCNH2 | |
| SCHEMBL9369050 | 0.69 | CHRM2 (0.54) | CHRM2CHRM1 | |
| SCHEMBL9490384 | 0.69 | CHRM2 (0.57) | CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239309-B1 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-01-12 | — | — | EP | claimed |
| CN-87102972-A | Treatment senile dementia oxadiazoles useful | — | 1987-11-18 | — | — | CN | claimed |
| EP-0239309-A2 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1987-09-30 | — | — | EP | claimed |
| EP-0586525-A1 | CARBOXAMIDO-(1,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES. | UPJOHN CO (US) | 1994-03-16 | — | — | EP | disclosed |
| EP-0239309-B1 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-01-12 | — | — | EP | disclosed |
| CN-87102972-A | Treatment senile dementia oxadiazoles useful | — | 1987-11-18 | — | — | CN | disclosed |
| EP-0239309-A2 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1987-09-30 | — | — | EP | disclosed |