Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.61 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MRE11 | P49959 | 1/20 | 0.44 |
| ▸ | MPL | P40238 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373930 | 0.93 | ROCK1 (0.56) | ROCK1ROCK2GSTO1LMNAFAAH | |
| SCHEMBL9370685 | 0.89 | GSTO1 (0.61) | ROCK1ROCK2GSTO1LMNAFAAH | |
| SCHEMBL9370963 | 0.89 | ROCK1 (0.61) | ROCK1ROCK2LMNAFAAHCNR2 | |
| SCHEMBL9370879 | 0.88 | ROCK1 (0.52) | ROCK1ROCK2FAAHKCNQ1CNR2 | |
| SCHEMBL9376475 | 0.88 | GSTO1 (0.49) | ROCK1ROCK2GSTO1KCNQ1ALOX5 | |
| SCHEMBL9371121 | 0.87 | ROCK1 (0.62) | ROCK1ROCK2GSTO1LMNAFAAH | |
| SCHEMBL9374885 | 0.86 | ROCK1 (0.61) | ROCK1ROCK2LMNAFAAHCNR2 | |
| SCHEMBL9370393 | 0.86 | ROCK1 (0.61) | ROCK1ROCK2LMNAFAAHCNR2 | |
| SCHEMBL9373539 | 0.85 | ROCK1 (0.59) | ROCK1ROCK2GSTO1LMNAFAAH | |
| SCHEMBL9373649 | 0.84 | GSTO1 (0.60) | ROCK1ROCK2GSTO1LMNAFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |