SCHEMBL9370516

SCHEMBL9370516

CCOC(=O)CC1(Cc2ccncc2)c2ccccc2-c2ccccc21

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNQ2 O43526 3/20 0.54
CYP1A2 P05177 2/20 0.54
CYP3A4 P08684 2/20 0.54
CYP2C9 P11712 2/20 0.54
ALOX15 P16050 1/20 0.54
TSHR P16473 1/20 0.54
ALDH1A1 P00352 4/20 0.43
ALDH2 P05091 1/20 0.43
ALDH3A1 P30838 1/20 0.43
ATM Q13315 1/20 0.42
GAA P10253 2/20 0.41
KDM4E B2RXH2 1/20 0.41
PPID Q08752 1/20 0.41
CDC7 O00311 2/20 0.39
DBF4 Q9UBU7 2/20 0.39
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
THPO P40225 1/20 0.38
PDK2 Q15119 1/20 0.38
NAMPT P43490 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8127736 0.99 KCNQ2 (0.52) KCNQ2CYP1A2CYP3A4CYP2C9ALOX15
Hydrochloric Acid SCHEMBL8377631 0.87 KCNQ2 (0.43) KCNQ2CYP1A2CYP3A4CYP2C9ALOX15
SCHEMBL9543487 0.85 KCNQ2 (0.49) KCNQ2CYP1A2CYP3A4CYP2C9ALOX15
Hydrochloric Acid SCHEMBL8120316 0.84 KCNQ2 (0.48) KCNQ2CYP1A2CYP3A4CYP2C9ALOX15
SCHEMBL24981178 0.82 ALDH1A1 (0.44) CYP1A2TSHRALDH1A1ATMGAA
SCHEMBL17051306 0.82 APEX1 (0.47) CYP1A2TSHRALDH1A1ATMGAA
SCHEMBL8111094 0.79 KCNQ2 (0.48) KCNQ2CYP1A2CYP3A4CYP2C9ALOX15
Hydrochloric Acid SCHEMBL8111088 0.78 KCNQ2 (0.47) KCNQ2CYP1A2CYP3A4CYP2C9ALOX15
Hydrochloric Acid SCHEMBL8111092 0.78 KCNQ2 (0.47) KCNQ2CYP1A2CYP3A4CYP2C9ALOX15
Water SCHEMBL8120263 0.78 KCNQ2 (0.59) KCNQ2CYP1A2CYP3A4CYP2C9ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0623132-A1 DISUBSTITUTED POLYCYCLIC SYSTEMS AS COGNITION ENHANCERS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-11-09 EP disclosed
WO-1993014092-A1 DISUBSTITUTED POLYCYCLIC SYSTEMS AS COGNITION ENHANCERS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-07-22 WO disclosed