Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT1 | P24752 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740649 | 0.96 | ACAT1 (0.72) | ACAT1 | |
| SCHEMBL9370614 | 0.92 | ACAT1 (0.78) | ACAT1 | |
| SCHEMBL9374338 | 0.92 | ACAT1 (0.66) | ACAT1 | |
| SCHEMBL9370818 | 0.90 | ACAT1 (0.71) | ACAT1 | |
| Lecimibide SCHEMBL9879864 | 0.89 | ACAT1 (0.93) | ACAT1 | |
| SCHEMBL9424523 | 0.89 | — | — | |
| SCHEMBL9370240 | 0.89 | — | — | |
| SCHEMBL9370575 | 0.89 | — | — | |
| SCHEMBL9373133 | 0.88 | ACAT1 (0.69) | ACAT1 | |
| SCHEMBL9375520 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5318984-A | Anticholesterol agents which inhibit acetyl coenzyme A transferase | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0372445-B1 | Imidazoles for the treatment of atherosclerosis | DU PONT MERCK PHARMA (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5166214-A | Enzyme inhibitors for anticholesterol agents, enzyme inhibitor and cardiovascular disorders | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-24 | — | — | US | disclosed |
| WO-1991018885-A1 | IMIDAZOLES FOR THE TREATMENT OF ATHEROSCLEROSIS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-12 | — | — | WO | disclosed |
| EP-0372445-A1 | Imidazoles for the treatment of atherosclerosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-06-13 | — | — | EP | disclosed |