⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374514 | 0.91 | PTGIR (0.50) | — | |
| Formic Acid SCHEMBL28279122 | 0.91 | PTGIR (0.50) | — | |
| SCHEMBL2374517 | 0.91 | PTGIR (0.50) | — | |
| SCHEMBL6345787 | 0.91 | PTGIR (0.49) | — | |
| SCHEMBL23851385 | 0.89 | PLG (0.50) | — | |
| SCHEMBL1118701 | 0.89 | PLG (0.50) | — | |
| SCHEMBL16888038 | 0.89 | PTGIR (0.49) | — | |
| SCHEMBL6517561 | 0.89 | PLG (0.50) | — | |
| SCHEMBL9132825 | 0.89 | LMNA (0.53) | — | |
| SCHEMBL2346158 | 0.89 | LMNA (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018109781-A1 | A PROCESS FOR THE PREPARATION OF FIROCOXIB | SEQUENT SCIENTIFIC LIMITED (IN) | 2018-06-21 | — | — | WO | claimed |
| EP-1218366-B1 | METHOD FOR PRODUCING COX-2 INHIBITORS | MERIAL SAS (FR) | 2005-09-14 | — | — | EP | claimed |
| US-6541646-B2 | Reacting an oxirane compound containing phenylsulfonyl group with an acid in an anhydrous medium to form an intermediate, reacting the intermediate with a storng base in an aprotic solvent to form an ester compound,dehydrating the ester comp. | MERIAL (FR) | 2003-04-01 | — | — | US | claimed |
| US-20030028036-A1 | Method of preparing COX-2 inhibitors | MERIAL (FR) | 2003-02-06 | — | — | US | claimed |
| US-20260083708-A1 | IL-17 MODULATORS AND USES THEREOF | NNOCARE PHARMA INC (US) | 2026-03-26 | — | — | US | disclosed |
| CN-114671864-B | Heteroaryl substituted pyridines and methods of use | 艾伯维公司 | 2025-04-08 | — | — | CN | disclosed |
| US-20230257352-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-08-17 | — | — | US | disclosed |
| US-20230257352-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-08-17 | — | — | US | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| CN-114671864-A | Heteroaryl substituted pyridines and methods of use | 艾伯维公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-110105314-B | Method for preparing feloxicib | 江苏君若药业有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-109311864-B | Heteroaryl substituted pyridines and methods of use | 艾伯维公司 | 2022-05-10 | — | — | CN | disclosed |
| EP-1218366-B8 | METHOD FOR PRODUCING COX-2 INHIBITORS | MERIAL SAS (FR) | 2005-11-09 | — | — | EP | disclosed |
| EP-1218366-B1 | METHOD FOR PRODUCING COX-2 INHIBITORS | MERIAL SAS (FR) | 2005-09-14 | — | — | EP | disclosed |
| US-20050065143-A1 | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2005-03-24 | — | — | US | disclosed |
| WO-2005011655-A2 | PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2005-02-10 | — | — | WO | disclosed |
| US-6541646-B2 | Reacting an oxirane compound containing phenylsulfonyl group with an acid in an anhydrous medium to form an intermediate, reacting the intermediate with a storng base in an aprotic solvent to form an ester compound,dehydrating the ester comp. | MERIAL (FR) | 2003-04-01 | — | — | US | disclosed |
| US-20030028036-A1 | Method of preparing COX-2 inhibitors | MERIAL (FR) | 2003-02-06 | — | — | US | disclosed |
| EP-1218366-A2 | METHOD FOR PRODUCING COX-2 INHIBITORS | MERIAL (FR) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001027098-A2 | METHOD FOR PRODUCING COX-2 INHIBITORS | MERIAL (FR) | 2001-04-19 | — | — | WO | disclosed |