Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371276 | 0.78 | ALDH1A1 (0.47) | LMNAALDH1A1NPSR1ENPP1KDM4E | |
| SCHEMBL9332582 | 0.70 | — | — | |
| SCHEMBL7894373 | 0.70 | ALDH1A1 (0.47) | LMNAALDH1A1NPSR1ENPP1KDM4E | |
| SCHEMBL9601687 | 0.69 | ALDH1A1 (0.45) | LMNAALDH1A1NPSR1KDM4EGAA | |
| SCHEMBL9344423 | 0.67 | — | — | |
| SCHEMBL9372842 | 0.65 | — | — | |
| SCHEMBL12125309 | 0.65 | ALDH1A1 (0.38) | LMNAALDH1A1NPSR1ENPP1KDM4E | |
| SCHEMBL12395328 | 0.65 | ALDH1A1 (0.38) | LMNAALDH1A1NPSR1ENPP1KDM4E | |
| SCHEMBL18879005 | 0.65 | ALDH1A1 (0.38) | LMNAALDH1A1NPSR1ENPP1KDM4E | |
| SCHEMBL11813721 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281367-B1 | Substituted 1,2,4-triazolo[1,5-a]triazines as bronchodilators | RIKER LABORATORIES INC (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0281367-A1 | Substituted 1,2,4-triazolo[1,5-a]triazines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1988-09-07 | — | — | EP | disclosed |
| US-4734413-A | Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1988-03-29 | — | — | US | disclosed |