Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL26696535 | 0.87 | HIF1A (0.64) | HIF1ASNCATSHRHTR2AALDH1A1 | |
| Bromide SCHEMBL2767870 | 0.82 | HIF1A (0.64) | HIF1ASNCATSHRHTR2AALDH1A1 | |
| Bromide SCHEMBL9955351 | 0.81 | HIF1A (0.52) | HIF1ASNCALMNATSHRALDH1A1 | |
| Bromide SCHEMBL8745323 | 0.81 | HIF1A (0.52) | HIF1ASNCASIGMAR1TSHRHTR2A | |
| SCHEMBL31526396 | 0.80 | HIF1A (0.67) | HIF1ASNCATSHRHTR2AALDH1A1 | |
| SCHEMBL6547318 | 0.78 | SIGMAR1 (0.54) | MEN1KMT2ASIGMAR1CYP2D6MAOA | |
| Hydrochloric Acid SCHEMBL11228418 | 0.78 | HIF1A (0.64) | HIF1ASNCATSHRHTR2AALDH1A1 | |
| Iodide SCHEMBL15577648 | 0.78 | HIF1A (0.64) | HIF1ASNCATSHRHTR2AALDH1A1 | |
| Bromide SCHEMBL8745302 | 0.78 | HIF1A (0.52) | HIF1ASNCAKMT2ASIGMAR1TSHR | |
| Bromide SCHEMBL2768948 | 0.78 | HIF1A (0.52) | HIF1ASNCALMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600084-A1 | INDOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |