Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.59 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GPR3 | P46089 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinazolinone SCHEMBL27983253 | 0.74 | PARP1 (1.00) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| SCHEMBL914338 | 0.74 | PDPK1 (0.59) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL88525 | 0.74 | PARP1 (1.00) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL30408864 | 0.72 | PARP1 (0.96) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL22442340 | 0.72 | PARP1 (0.96) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL8201420 | 0.72 | PARP1 (0.96) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL28314056 | 0.72 | PARP1 (0.96) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| SCHEMBL20998623 | 0.72 | PARP1 (0.96) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL29603643 | 0.72 | PARP1 (0.96) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL27896056 | 0.72 | PARP1 (0.96) | SMN1; SMN2PDPK1CA12PARP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104151255-B | A kind of polysubstituted quinazoline imine derivative and preparation method thereof | 清华大学 | 2016-07-13 | — | — | CN | disclosed |
| EP-0411766-B1 | Substituted quinazolinones as angiotensin II antagonists | MERCK & CO INC (US) | 1994-01-19 | — | — | EP | disclosed |
| US-5240928-A | Hypotensive agents | MERCK & CO., INC. (US) | 1993-08-31 | — | — | US | disclosed |
| US-5238942-A | Hypotensive agents | MERCK & CO., INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0512870-A1 | Substituted quinazolinones bearing acidic functional groups as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |
| EP-0411766-A1 | Substituted quinazolinones as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-02-06 | — | — | EP | disclosed |