Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373071 | 0.93 | PPARG (0.56) | PPARGMAPTFFAR1MAOBCA2 | |
| SCHEMBL9372697 | 0.85 | PPARG (0.68) | PPARGMAPTFFAR1MAOBCA2 | |
| SCHEMBL6866703 | 0.82 | PPARG (0.71) | PPARGMAPTFFAR1MAOBCA2 | |
| SCHEMBL166570 | 0.79 | PPARG (0.74) | PPARGMAPTFFAR1MAOBCA2 | |
| SCHEMBL9374608 | 0.79 | PPARG (0.56) | PPARGMAPTFFAR1MAOBCA2 | |
| SCHEMBL9371198 | 0.77 | PPARG (0.57) | PPARGMAPTFFAR1MAOBCA2 | |
| SCHEMBL8208034 | 0.77 | PPARG (0.51) | PPARGMAPTFFAR1MAOBCA2 | |
| SCHEMBL9372644 | 0.76 | PPARG (0.61) | PPARGMAPTFFAR1MAOBCA2 | |
| SCHEMBL9374638 | 0.76 | PPARG (0.56) | PPARGMAPTFFAR1MAOBCA2 | |
| SCHEMBL9376787 | 0.76 | PPARG (0.56) | PPARGMAPTFFAR1MAOBCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332331-B1 | Thiazolidinedione hypoglycemic agents | PFIZER (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5223522-A | Anticholesterol agents | PFIZER INC. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5120754-A | Anticholesterol and antidiabetic agents | PFIZER INC. (US) | 1992-06-09 | — | — | US | disclosed |
| US-5061717-A | ANTICHOLESTEROL AGENTS | PFIZER INC. (US) | 1991-10-29 | — | — | US | disclosed |
| WO-1989008650-A1 | THIAZOLIDINEDIONE HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |
| EP-0332331-A2 | Thiazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |