SCHEMBL8208034

SCHEMBL8208034

O=C1NC(=O)C(CCCc2ccccc2)S1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 3/20 0.51
CA2 P00918 2/20 0.46
MAOB P27338 2/20 0.46
MAPT P10636 1/20 0.46
KDM4E B2RXH2 1/20 0.46
TSHR P16473 1/20 0.46
HTT P42858 1/20 0.46
FFAR1 O14842 2/20 0.44
MAOA P21397 2/20 0.43
CISD1 Q9NZ45 2/20 0.43
KMT2A Q03164 1/20 0.42
HDAC3 O15379 1/20 0.41
MAPK1 P28482 1/20 0.41
ADRA1A P35348 1/20 0.41
HDAC4 P56524 1/20 0.41
SLC6A3 Q01959 1/20 0.41
HDAC1 Q13547 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8889930 0.86 MAPT (0.49) PPARGMAOBMAPTKDM4ETSHR
SCHEMBL9372697 0.84 PPARG (0.68) PPARGCA2MAOBMAPTKDM4E
SCHEMBL8165382 0.84 CA2 (0.68) PPARGCA2MAOBMAOAKMT2A
SCHEMBL8899380 0.81 MAPT (0.48) PPARGMAOBMAPTKDM4ETSHR
SCHEMBL6866703 0.81 PPARG (0.71) PPARGCA2MAOBMAPTKDM4E
SCHEMBL166570 0.80 PPARG (0.74) PPARGCA2MAOBMAPTKDM4E
SCHEMBL19217794 0.79 FFAR1 (0.56) PPARGMAOBFFAR1MAOA
SCHEMBL8340601 0.79 PTPN1 (0.47) CA2HTTFFAR1KMT2A
SCHEMBL9375765 0.77 PPARG (0.54) PPARGCA2MAOBMAPTFFAR1
SCHEMBL6966826 0.76 PPARG (0.50) PPARGKDM4EFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000018746-A1 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS ROCHE DIAGNOSTICS GMBH (DE) 2000-04-06 WO disclosed