Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 15/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375807 | 1.00 | HPGD (0.62) | HPGDPTPN1MAOAMAOBPOLB | |
| SCHEMBL9379554 | 0.80 | HPGD (0.54) | HPGDPTPN1MAOAMAOBPOLB | |
| SCHEMBL9379550 | 0.80 | HPGD (0.54) | HPGDPTPN1MAOAMAOBPOLB | |
| SCHEMBL9372044 | 0.78 | HPGD (0.70) | HPGDPIM1PIM3PIM2 | |
| SCHEMBL9372040 | 0.78 | HPGD (0.70) | HPGDPIM1PIM3PIM2 | |
| SCHEMBL20637539 | 0.77 | HPGD (1.00) | HPGDPTPN1MAOAMAOBPOLB | |
| SCHEMBL19119626 | 0.77 | HPGD (1.00) | HPGDPTPN1MAOAMAOBPOLB | |
| SCHEMBL9371454 | 0.76 | ALDH1A1 (0.46) | NPC1RAB9A | |
| SCHEMBL1300347 | 0.73 | HPGD (1.00) | HPGDPTPN1MAOAMAOBPOLB | |
| SCHEMBL1300345 | 0.73 | HPGD (1.00) | HPGDPTPN1MAOAMAOBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332331-B1 | Thiazolidinedione hypoglycemic agents | PFIZER (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5223522-A | Anticholesterol agents | PFIZER INC. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5120754-A | Anticholesterol and antidiabetic agents | PFIZER INC. (US) | 1992-06-09 | — | — | US | disclosed |
| US-5061717-A | ANTICHOLESTEROL AGENTS | PFIZER INC. (US) | 1991-10-29 | — | — | US | disclosed |
| WO-1989008650-A1 | THIAZOLIDINEDIONE HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |
| EP-0332331-A2 | Thiazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |