Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28500412 | 0.88 | MAPT (0.67) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9589076 | 0.83 | PDE4B (0.59) | PDE4BMAPTPDE4DKDM4ETSHR | |
| SCHEMBL9588165 | 0.82 | PDE4B (0.58) | PDE4BMAPTPDE4DKDM4ETSHR | |
| SCHEMBL9375457 | 0.81 | HDAC3 (0.57) | PDE4BMAPTPDE4DKDM4ETSHR | |
| SCHEMBL9590166 | 0.79 | PDE4B (0.55) | PDE4BMAPTPDE4DHPGDHDAC3 | |
| SCHEMBL7334285 | 0.79 | CA12 (0.69) | PDE4BHTTPDE4DTSHRHPGD | |
| SCHEMBL9589259 | 0.78 | PDE4B (0.62) | PDE4BMAPTSMN1; SMN2PDE4DTSHR | |
| SCHEMBL2499200 | 0.76 | MAPT (0.60) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL7175524 | 0.76 | PDE4B (0.59) | PDE4BMAPTSMN1; SMN2PDE4DTSHR | |
| SCHEMBL7340408 | 0.74 | PDE4B (0.57) | PDE4BMAPTSMN1; SMN2PDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607217-A1 | PYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-27 | — | — | EP | disclosed |
| WO-1993007137-A1 | PYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1993-04-15 | — | — | WO | disclosed |