Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8597038 | 0.90 | TSHR (0.56) | MAPTALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL6280285 | 0.90 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL7455682 | 0.89 | RAB9A (0.51) | MAPTALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL5685561 | 0.88 | ALDH1A1 (0.56) | MAPTALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL6281258 | 0.88 | MAPT (0.56) | MAPTALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL7455153 | 0.88 | SMPD1 (0.57) | MAPTALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL28500412 | 0.87 | MAPT (0.67) | MAPTALDH1A1SMN1; SMN2RAB9AHSD11B1 | |
| SCHEMBL342810 | 0.82 | ALDH1A1 (0.53) | MAPTALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL2395083 | 0.81 | ALDH1A1 (0.65) | MAPTALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL11599893 | 0.81 | ALDH1A1 (0.59) | MAPTALDH1A1SMN1; SMN2LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132194-A1 | PROCESS FOR THE PREPARATION OF RALOXIFENE HYDROCHLORIDE | HETERO RESEARCH FOUNDATION (IN) | 2011-10-27 | — | — | WO | claimed |
| WO-2011132194-A1 | PROCESS FOR THE PREPARATION OF RALOXIFENE HYDROCHLORIDE | HETERO RESEARCH FOUNDATION (IN) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132194-A1 | PROCESS FOR THE PREPARATION OF RALOXIFENE HYDROCHLORIDE | HETERO RESEARCH FOUNDATION (IN) | 2011-10-27 | — | — | WO | disclosed |
| US-8030330-B2 | Benzothiophenes, formulations containing same, and methods | ELI LILLY AND COMPANY (US) | 2011-10-04 | — | — | US | disclosed |
| US-20100255106-A1 | BENZOTHIOPHENES, FORMULATIONS CONTAINING SAME, AND METHODS | ARBUTHNOT GORDON NELSON | 2010-10-07 | — | — | US | disclosed |
| WO-2005003116-A9 | PROCESS FOR PREPARING RALOXIFENE HYDROCHLORIDE | ERREGIERRE SPA (IT) | 2008-09-25 | — | — | WO | disclosed |
| EP-1641773-B1 | PROCESS FOR PREPARING RALOXIFENE HYDROCHLORIDE | ERREGIERRE SPA (IT) | 2008-07-23 | — | — | EP | disclosed |
| US-20070100147-A1 | Process for preparing raloxifene hydrochloride | ERREGIERRE S.P.A (IT) | 2007-05-03 | — | — | US | disclosed |
| EP-1641773-A1 | PROCESS FOR PREPARING RALOXIFENE HYDROCHLORIDE | ERREGIERRE S.p.A. (IT) | 2006-04-05 | — | — | EP | disclosed |
| US-7012153-B2 | Process for preparing benzoic acids | ELI LILLY AND COMPANY (US) | 2006-03-14 | — | — | US | disclosed |
| US-4656187-A | SYNERGISTIC COMBINATION | ELI LILLY AND COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0062504-B1 | PROCESS FOR PREPARING 3-(4-AMINOETHOXYBENZOYL)BENZO(B)THIOPHENES | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | disclosed |
| EP-0062505-B1 | A PROCESS FOR PREPARING ACYLATED BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 1985-07-24 | — | — | EP | disclosed |
| US-4418068-A | Antiestrogenic and antiandrugenic benzothiophenes | ELI LILLY AND COMPANY (US) | 1983-11-29 | — | — | US | disclosed |
| US-4380635-A | Synthesis of acylated benzothiophenes | ELI LILLY AND COMPANY (US) | 1983-04-19 | — | — | US | disclosed |
| US-4358593-A | BY ACYLATION OF PROTECTED 6-HYDROXY,2-(4-HYDROXYPHENYL) BENZO (B)THIOPHENE USING A FRIEDEL CRAFTS CATALYSTS; HYDROLYSIS | ELI LILLY AND COMPANY (US) | 1982-11-09 | — | — | US | disclosed |
| EP-0062503-A1 | Benzothiophene compounds and process for preparing them | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| EP-0062504-A1 | Process for preparing 3-(4-aminoethoxybenzoyl)benzo(b)thiophenes | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| EP-0062505-A1 | A process for preparing acylated benzothiophenes | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| US-4133814-A | ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1979-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070100147-A1 | Process for preparing raloxifene hydrochloride | KAT2A, ADH1A, KAT2B | MAPT 4172/4885ALDH1A1 152/4885SMN1; SMN2 4028/4885 |
| US-20100255106-A1 | BENZOTHIOPHENES, FORMULATIONS CONTAINING SAME, AND METHODS | BRCA1, CYP19A1, CYP46A1 | MAPT 109/4885ALDH1A1 1786/4885SMN1; SMN2 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.